Brain Immune System is Key to Recovery from Motor Neuron Degeneration

Researchers engineered mice in which the damage caused by a mutant human TDP-43 protein could be reversed by one type of brain immune cell. TDP-43 is a protein that misfolds and accumulates in the motor areas of the brains of ALS patients. They found that microglia, the first and primary immune response cells in the brain and spinal cord, are essential for dealing with TDP-43-associated neuron death.

Synaptic disorder

A Würzburg research team describes a hitherto unknown pathogenic mechanism of motor neuron disorders. This should lead to a rethinking in drug development. Motor neurons are the nerves that send impulses to the muscles to generate movement.