A new study sheds light into the function of microglia and inflammatory response.
Chronic Stress Drives Immune Cells to Remodel Neural Circuits, Possibly Promoting Anxiety and Depression
New research shows how stress triggers the brain’s resident immune cells, called microglia, to remodel neural circuits, leading to synaptic changes associated with anxiety and depression.
A new discovery about the immune system may allow doctors to treat harmful inflammation that damages the brain in neurodegenerative diseases such as Alzheimer’s.
Researchers engineered mice in which the damage caused by a mutant human TDP-43 protein could be reversed by one type of brain immune cell. TDP-43 is a protein that misfolds and accumulates in the motor areas of the brains of ALS patients. They found that microglia, the first and primary immune response cells in the brain and spinal cord, are essential for dealing with TDP-43-associated neuron death.
Alzheimer’s disease, a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure.