This part of the PFC helps us make decisions based on the bigger picture gathered from connections to the amygdala, temporal lobe, ventral segmental area, olfactory system, and the thalamus. It is very well connected, receiving and sending a lot of information that influences many brain regions, including the amygdala. The vmPFC plays an important role with the OFC in regulating our emotions, especially in social situations. It is also vital for personal and social decision making and the ability to learn from our mistakes. Our capacity to make judgements and allow our emotions to assist in decision making is mediated by this region of the brain. Activation of the vmPFC is also associated with courage, suppression of negative emotions, compassion, shame, and guilt.
