Australian researchers hope to reduce unnecessary CT scans and radiation exposure in children with head injuries, following the results from a large-scale, multicentre validation study to assess the diagnostic accuracy of three clinical decision rules used by emergency doctors.

Head injuries are one of the most common reasons children are taken to Australian emergency departments. To rule out a serious brain injury, a percentage of these children require a CT scan and while this process is obvious for serious head injuries, it’s more challenging to determine whether CT scans are necessary for children with milder injuries.

The research group’s findings will help inform the use of the clinical decision rules for head injuries, which in turn could minimise CT scans, according to Lead investigator, Murdoch Children’s Research Institute’s Associate Professor Franz Babl.

“The aim of this study was to determine which children need CT scans to detect brain injury,” said A/Prof Babl.

“Most head injuries are mild and don’t require neurosurgical management, however, a small proportion of patients might present as having mild injuries, but have clinically significant intracranial injuries,” he said.

“This can be a vexed issue because physicians need to balance the importance of diagnosing an injury with reducing radiation exposure as much as possible.

“The preferred course of treatment is to avoid a CT scan in minor head injuries if it is unnecessary.  In particular, there is concern about the high radiation dose associated with CT scans of the head which can lead to cancer.”

In these cases, clinicians can turn to clinical decision rules, which have been developed to identify children at high risk of intracranial injuries, aiming to assist clinicians to minimise CT scans while still identifying all relevant injuries.

In a prospective observational study, run across 10 Australian and New Zealand tertiary hospitals and involving, 20,137 children under the age of 18 years with head injuries, the research team compared three clinical decision rules:

  • The Pediatric Emergency Care Applied Research Network (PECARN, USA)
  • The Canadian Assessment of Tomography for Childhood Head Injury (CATCH) rule
  • The Children’s Head Injury Algorithm for the Prediction of Important Clinical Events (CHALICE, UK).

Head injury

The goal was to determine which of these three decision rules provided the best option when it came to identifying children at very low risk of a traumatic brain injury. The researchers found that all three rules were good options, but only one, the PECARN from the US, did not miss a single patient requiring neurosurgery.

Based on the research findings, the next step is for the group of emergency physicians to develop national approaches to optimise the management of children with head injuries in Australia and New Zealand.

Internationally, the findings will provide a useful starting point for individual clinicians as well as hospitals or regional bodies contemplating the introduction or modification of one of the clinical decision rules, according to A/Prof Babl.

“However, it will be important to relate the findings to a number of other factors before implementation, such as the baseline CT use, the effect of the rules on the projected CT rate, the baseline clinician diagnostic accuracy and experience, parental expectations, the medico-legal climate and economic considerations.”

The clinical trial results were recently published in the prestigious medical journal, The Lancet.

In The Lancet article, the researchers commented that patients reflected an Australia and New Zealand cohort from tertiary children’s hospitals, which had much lower neuro-imaging rates than those reported from the USA and Canada.

The study was run by clinicians involved in the PREDICT network (Paediatric Research in Emergency Departments International Collaborative). They received grants totalling AU$1.391 million from the National Health and Medical Research Council (NHMRC), the Emergency Medicine Foundation of Australia (EMF), Perpetual Philanthropic Services, Murdoch Childrens Research Institution, WA Health Targeted Research Funds, Townsville Hospital Practice fund, Auckland Medical Research Foundation, the A+ Trust, and the Victorian Government’s Infrastructure Support Program.

The $298,000 EMF grant, funded by Queensland Health, enabled the study to run at the former Royal Children’s Hospital and the Mater Children’s Hospital in Brisbane (now merged into the Lady Cilento Children’s Hospital) and The Townsville Hospital.

Other hospitals participating in the study included: Royal Children’s Hospital, Melbourne; Princess Margaret Hospital, Perth; Monash Children’s Hospital, Melbourne; Kidzfirst Middlemore Hospital, New Zealand; Starship Hospital, Auckland; Women’s and Children’s Hospital, Adelaide; and The Children’s Hospital at Westmead, Sydne

Source: Emergency Medical Foundation

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